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RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 143-155 doi: 10.1007/s11684-022-0929-y

Abstract: Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressorMoreover, RGS16 was validated as a direct target gene of miR let-7c-5p.The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking downmiR let-7c-5p had the opposite effect.Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may

Keywords： RGS16     let-7c-5p     glioma     proliferation     migration    

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: investigated five Chinese families with EB, and eight variants including a novel nonsense variant (c.47G>A, p.W16*) in LAMA3, a known recurrent variant (c.74C>T, p.P25L) in KRT5, 2 novel (c.2531T>A, p.V844E; c.6811_6814del, p.R2271fs) and 4 known (c.6187C>T, p.R2063W; c.7097G>A, p.G2366D; c.8569G>T, p.E2857*; c.3625_3635del, p.S1209fs) variants in COL7A1 were detected.

Keywords： epidermolysis bullosa     LAMA3     COL7A1     KRT5     Chinese families    

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A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO

Jing DONG, Huilong WANG

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 245-251 doi: 10.1007/s11705-010-1003-x

Abstract: and convenient method for the determination of ClO in water was developed by using acid chrome black 7(MB 7) spectrophotometry in this paper.

Keywords： chlorine dioxide     2     6-dinitro-p-cresol (DNPC)     aluminum oxide     water treatment     MB 7 spectrophotometry    

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First Pig-to-Live Human Xenotransplant Produces Mixed Results

Sarah C.P. Williams

Engineering 2022, Volume 16, Issue 9,   Pages 6-8 doi: 10.1016/j.eng.2022.07.006

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CRISPR Narrows Gap between Genetically Altered Foods and Consumers

Sarah C.P. Williams

Engineering 2023, Volume 20, Issue 1,   Pages 6-8 doi: 10.1016/j.eng.2022.11.002

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Geoengineering Research Moves from Laboratory to Field News & Highlights

Sarah C.P. Williams

Engineering 2023, Volume 27, Issue 8,   Pages 3-5 doi: 10.1016/j.eng.2023.06.004

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Advancing Genomic Science Opens Windows to the Past

Sarah C.P. Williams

Engineering 2023, Volume 26, Issue 7,   Pages 9-11 doi: 10.1016/j.eng.2023.05.003

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Non-thermal plasma for exhaust gases treatment

,Marquidia PACHECO P.,Fernando GÓMEZ B.,Joel PACHECO P.,Arturo COLÍN C.,José HUERTAS C.,Hilda FRÍAS P.

Frontiers of Mechanical Engineering 2015, Volume 10, Issue 3,   Pages 301-305 doi: 10.1007/s11465-015-0344-z

Abstract: <p>This article describes a study on a non-thermal plasma device to treat exhaust gases in an internalp>

Keywords： plasma treatment     NOx     CO     CO2     particulate matter     vehicle    

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Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 150-155 doi: 10.1007/s11684-021-0846-5

Abstract: The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9.plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence causedOverall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5

Keywords： cystic fibrosis     CFTR     splicing mutation     minigene    

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Funding Bonanza Lifts CO2 Removal Technology to Demonstration Phase

Sarah C.P. Williams

Engineering 2023, Volume 22, Issue 3,   Pages 7-9 doi: 10.1016/j.eng.2023.01.002

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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinineCirculating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR);UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESRElevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF,TNF-α, TGF-β1, and FN and negatively correlated with eGFR ( <0.05). miR-154-5p, HbA1c, sCr, BUN, eGFR

Keywords： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 331-343 doi: 10.1007/s11684-015-0409-8

Abstract: In this study, miRNA profiling and qRT-PCR validation revealed that miR-142-3p and miR-142-5p were significantlyOverexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression ofboth synergistically inhibited cell migration, which indicated that miR-142-3p and miR-142-5p may cooperativelyregulate cell movement. miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3′miR-142-5p with several cell motility-associated pathways, including those regulating actin cytoskeleton

Keywords： hepatocellular carcinoma     microRNA     metastasis     cytoskeletal reorganization    

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Effective Anti-Obesity Drugs Make Losing Weight a Big Deal

Sarah C. P. Williams

Engineering 2024, Volume 32, Issue 1,   Pages 4-6 doi: 10.1016/j.eng.2023.11.005

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: , impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagyNotably, miR-193-5p overexpression decreased plaque size and increased collagen content.In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

Keywords： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Frontiers of Medicine doi: 10.1007/s11684-023-1016-8

Abstract: p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved.mutations (P = 0.037) and poor overall survival (OS) (P = 0.010).DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53.induced strong immune responses featuring the striking upregulation of the innate immune player IRF77 as a potential biomarker for decitabine-based treatments.

Keywords： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

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Title Author Date Type Operation

RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

A study on rapid acid chrome black (MB 7) spectrophotometric determination of ClO

Jing DONG, Huilong WANG

Journal Article

First Pig-to-Live Human Xenotransplant Produces Mixed Results

Sarah C.P. Williams

Journal Article

CRISPR Narrows Gap between Genetically Altered Foods and Consumers

Sarah C.P. Williams

Journal Article

Geoengineering Research Moves from Laboratory to Field

Sarah C.P. Williams

Journal Article

Advancing Genomic Science Opens Windows to the Past

Sarah C.P. Williams

Journal Article

Non-thermal plasma for exhaust gases treatment

,Marquidia PACHECO P.,Fernando GÓMEZ B.,Joel PACHECO P.,Arturo COLÍN C.,José HUERTAS C.,Hilda FRÍAS P.

Journal Article

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

Journal Article

Funding Bonanza Lifts CO2 Removal Technology to Demonstration Phase

Sarah C.P. Williams

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Journal Article

Effective Anti-Obesity Drugs Make Losing Weight a Big Deal

Sarah C. P. Williams

Journal Article

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical

Journal Article